Major customer service problems with Vistaprint's punctuality and customer focus. Currently, OvernightPrints.com is delivering for us.
Agree with others that it would be good to know which industry you're in. There's a company called ARC Document Solutions that has an excellent cloud management solution & nationwide printing locations. They work really well for construction, real estate, retail, etc. For a more standard consumer use case (e.g., printing flyers or postcards), I second PFL or VistaPrint.