I worry that your question is both too vague for the average person to understand what you're asking, and too specific in that most readers here are not in or familiar with Portugal, let alone Lisbon, to give you useful advice.
I would suggest you look at the issue the same way any business concept should be evaluated. Research, research, research. Find a problem that needs a solution, not a product that needs a location.
What is your target market? What are you selling? For me. email marketing is my solution for b2b, while social media marketing for b2c. However, the pandemic greatly affected businesses.
I think I can help you transform your business until you are back to normal or let me know by pm about what you want to do :)
I think I know your place :--) I used to work with the Lupi family and still have people working for me in Setubal.